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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK4
All Species:
25.15
Human Site:
S245
Identified Species:
42.56
UniProt:
Q9NR20
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR20
NP_003836.1
520
59608
S245
L
Y
Q
K
G
Q
A
S
V
K
V
I
D
F
G
Chimpanzee
Pan troglodytes
XP_001158495
520
59654
S245
L
Y
Q
K
G
Q
A
S
V
K
V
I
D
F
G
Rhesus Macaque
Macaca mulatta
XP_001101112
520
59434
S245
L
Y
Q
K
G
Q
V
S
V
K
V
I
D
F
G
Dog
Lupus familis
XP_534917
565
65190
S293
L
Y
Q
K
G
Q
V
S
V
K
V
I
D
F
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8BI55
632
72542
T360
L
Y
Q
R
G
Q
V
T
V
K
V
I
D
F
G
Rat
Rattus norvegicus
Q4V8A3
586
65492
A315
V
Q
L
V
R
K
F
A
Q
S
I
L
Q
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509988
466
52101
F206
R
N
H
L
C
I
T
F
E
L
L
G
I
N
L
Chicken
Gallus gallus
Q5ZIU3
526
59419
A254
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
Frog
Xenopus laevis
Q2TAE3
750
84138
A294
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
Zebra Danio
Brachydanio rerio
XP_693389
634
72240
N353
L
S
Q
R
G
Q
G
N
I
K
V
V
D
F
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3D5
722
79590
S339
L
K
Q
R
G
S
S
S
I
K
V
I
D
F
G
Honey Bee
Apis mellifera
XP_396369
614
68978
S324
L
K
Q
R
G
S
S
S
I
K
V
I
D
F
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51568
400
46206
D140
V
Q
M
K
N
W
F
D
Y
R
N
H
I
C
I
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
E511
L
C
A
P
D
K
P
E
L
K
I
I
D
F
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
89.2
76.9
N.A.
65.3
38.7
N.A.
54.2
43.1
28
48.9
N.A.
37.5
42.3
N.A.
N.A.
Protein Similarity:
100
99
91.5
81.2
N.A.
71.5
53.9
N.A.
66.1
59.7
43.3
61.8
N.A.
50.1
59.1
N.A.
N.A.
P-Site Identity:
100
100
93.3
93.3
N.A.
80
0
N.A.
0
6.6
33.3
60
N.A.
66.6
66.6
N.A.
N.A.
P-Site Similarity:
100
100
93.3
93.3
N.A.
93.3
33.3
N.A.
6.6
33.3
73.3
86.6
N.A.
86.6
86.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.8
22.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
15
22
0
0
0
0
0
0
0
% A
% Cys:
0
15
0
0
8
0
0
0
0
0
0
0
0
15
0
% C
% Asp:
0
0
0
0
8
0
0
8
0
0
0
0
72
0
0
% D
% Glu:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
22
8
0
0
0
0
0
72
0
% F
% Gly:
0
0
0
0
58
0
8
0
0
0
0
8
0
0
72
% G
% His:
0
0
8
0
0
0
0
0
8
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
29
0
29
58
15
0
8
% I
% Lys:
0
15
0
36
8
22
0
0
0
72
0
0
0
0
0
% K
% Leu:
79
0
15
8
0
0
0
0
8
8
8
15
0
0
22
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
0
8
0
0
8
0
0
8
0
0
8
0
% N
% Pro:
0
8
0
15
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
15
58
0
0
43
0
0
8
0
0
0
15
0
0
% Q
% Arg:
8
0
0
29
15
8
0
0
0
8
0
0
0
0
0
% R
% Ser:
0
8
0
0
0
15
22
43
0
15
0
0
0
8
0
% S
% Thr:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% T
% Val:
15
0
0
15
0
0
22
0
36
0
58
15
0
0
0
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
36
0
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _